gastric cancer thesis

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New thesis on stomach cancer

Johannes Asplund at the research group Upper GI Surgery, the Department of Molecular Medicine and Surgery, will defend his thesis "Towards an improved survival in gastric cancer" on November 25th, 2022. Main Supervisor is Jesper Lagergren.

What's the main focus of your thesis? 

Stomach cancer, with a focus on factors influencing patients’ survival after surgery.  

Which are the most important results? 

Incidence of cancer in the upper part of the stomach is increasing, while cancer in the middle and lower part is decreasing. For the decreasing proportion of patients being operated for their stomach cancer, survival is increasing, especially for those with cancer in the upper part of the stomach.  

Long-term survival does not seem to differ between patients with stomach cancer operated at hospitals with high volume of stomach surgery compared to low volume of surgery. Similarly, survival does not seem to differ between patients operated by surgeons with high volume compared to surgeons with low volume of surgery. But there is a learning curve for surgeons starting to operate stomach cancer during which long-term survival seems to be worse for the patient. 

How can this new knowledge contribute to the improvement of people's health? 

Information on changes in incidence and survival is important to understand effects of changes in detection and treatment over time. Knowledge of how surgeons’ operative volume and learning curves affect prognosis in stomach cancer is valuable for optimal strategic planning of health care, with the aim to improve survival for these patients.  

What are your future ambitions?  

During my time as a PhD-student I have collected data and worked with a large cohort of patients. This data base can provide answers to many yet unanswered questions. I plan to continue research with more studies on the subject.  

Dissertation 

Friday November 25, 2022 at 9:00, Aulan Södersjukhuset, Sjukhusbacken 10

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Epigenetic Mechanisms in Gastric Cancer Growth and Immunotherapy Responses

A dissertation submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Victoria, Australia.

• School of Cancer Medicine

Thesis type

Awarding institution, year awarded, rights statement, usage metrics.

• Epigenetics (incl. genome methylation and epigenomics)
• Oncology and carcinogenesis
• Tumour immunology

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Search for dissertations about: "thesis for gastric cancer"

Showing result 1 - 5 of 146 swedish dissertations containing the words thesis for gastric cancer .

1. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

Author : Anna Isinger Ekstrand ; Institutionen för immunteknologi ; [] Keywords : MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; Esophageal cancer ; hereditary cancer ; HNPCC ; copy number analysis ; CGH ; gene expression ; Wnt ; PIK3CA ; CHEK2 ; gastric cancer ; colorectal cancer ;

Abstract : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. READ MORE

2. Tumors associated with Hereditary Nonpolyposis Colorectal Cancer: Defective Mismatch Repair and Familial Risk of Cancer

Author : Kajsa Ericson Lindquist ; Bröstcancer-genetik ; [] Keywords : MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; oncology ; cancerology ; Cytologi ; onkologi ; cancer ; Multiple Tumors ; Hereditary Nonpolyposis Colorectal Cancer ; Cytology ; Cohort study ; Population based ; Familial Risk of Cancer ; Immunohistochemistry ; MSH2 ; MSH6 ; MLH1 ; Microsatellite Instability ; Soft Tissue Sarcomas ; Cancer of the Upper Urinary Tract ; Cancer of the Small Intestine ; Colorectal Cancer ;

Abstract : Inactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated sequences, and 90% of MSI tumors show loss of immunohistochemical expression for the MMR protein affected. READ MORE

3. Carbonate Ions and Gastric Cancer

Author : Roy Ehrnström ; Malmö Patologi ; [] Keywords : MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; MEDICAL AND HEALTH SCIENCES ; Medicine human and vertebrates ; ODC ; COX-2 ; inflammation ; Wistar rats ; duodenogastric reflux ; Medicin människa och djur ; proliferation ; gastrojejunostomy ; carbonate ions ; Experimental gastric cancer ;

Abstract : Nearly one million new cases of gastric cancer are diagnosed annually throughout the world. Even though the incidence has fallen dramatically in recent decades, this disease is still the second leading cause of cancer death in a global perspective. READ MORE

4. Towards improved oncological treatment of esophageal and gastric cancer. Clinical and translational studies

Author : David Borg ; Tumörmikromiljö ; [] Keywords : MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; Esophageal adenocarcinoma ; Gastric cancer ; PODXL ; Prognosis ; Prediction ; Chemotherapy dose intensity ; Dysphagia ; Radiotherapy ;

Abstract : BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. READ MORE

5. Genetic epidemiology of prostate cancer

Author : Fredrik Wiklund ; Henrik Grönberg ; Douglas Easton ; Umeå universitet ; [] Keywords : MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICIN OCH HÄLSOVETENSKAP ; MEDICAL AND HEALTH SCIENCES ; Oncology ; prostate cancer ; epidemiology ; genetics ; linkage analysis ; genome-wide scan ; Onkologi ; Oncology ; Onkologi ; Oncology ; onkologi ;

Abstract : Prostate cancer is a major health burden throughout the world, yet the etiology of prostate cancer is poorly understood. Evidence has accumulated supporting the existence of a hereditary form of this disease. READ MORE

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